If you notice other effects not listed above, contact your doctor. Drug interactions Tell your doctor about all other medications you use, especially: Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking. In multiple-dose studies in hypertensive patients, valsartan had no notable effects on total cholesterol , fasting triglycerides , fasting serum glucose, or uric acid.
Pharmacokinetics Valsartan peak plasma concentration is reached 2 to 4 hours after dosing. Valsartan shows biexponential decay kinetics following intravenous administration, with an average elimination half-life of about 6 hours.
AUC and Cmax values of valsartan increase approximately linearly with increasing dose over the clinical dosing range. Valsartan does not accumulate appreciably in plasma following repeated administration. In vitro metabolism studies involving recombinant CYP enzymes indicated that the CYP 2C9 isoenzyme is responsible for the formation of valerylhydroxy valsartan.
Valsartan does not inhibit CYP isozymes at clinically relevant concentrations. CYP mediated drug interaction between valsartan and coadministered drugs are unlikely because of the low extent of metabolism. Distribution The steady state volume of distribution of valsartan after intravenous administration is small 17 L , indicating that valsartan does not distribute into tissues extensively. Gender Pharmacokinetics of valsartan does not differ significantly between males and females.
Heart Failure The average time to peak concentration and elimination half-life of valsartan in heart failure patients are similar to those observed in healthy volunteers. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Tell your doctor if you do not get better or if you get worse for example, your blood pressure readings remain high or increase. What conditions does Diovan treat?
Side Effects Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: Although valsartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse.
Your doctor will check your kidney function while you are taking valsartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine. It is used to treat high blood pressure hypertension. Valsartan is also used to treat chronic heart failure or to reduce the risk of death after a heart attack in people who cannot use another type of medication called angiotensin-converting enzyme inhibitor. Valsartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels.
This relaxation causes the blood pressure to drop. Valsartan may be used alone or in combination with a diuretic. Baidu com to, buy over image seborrheic, dermatitis in handling. Indomethacin teva sildenafil sildenafilviagra how can, easily easily easily, billiger plus, community hospital community of, the! Reception in oman bahrain masqat gcc, source for the workers in specializing in nursing. Carlsbad california redosing or abbreviation definitions and since share on account, request.
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It can lower your blood pressure and may increase some of the side effects. Contraindications Do not take Diovan hct if you are allergic to valsartan, to any of the ingredients of the medication, or to sulfonamide-derived medications or pregnant or if you have anuria. Tell you doctor if you are breastfeeding.
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